Ethylene Dichloride Disruption of Fertility in Male Mice

P-22: Protective Effect of Grapes SeedHydroalcholic Extract against Fluoxetine-Induced Fertility Toxicity in Male Mice

Background: Fluoxetine, a selective serotonin reuptake inhibitor, has been prescribed for the treatment of depression and has shown also efficacy in the treatment of bulimia nervosa and obsessive-compulsive disorder. Grape seed extract is a natural extract from the seeds of graps. It contains the most beneficial groups of plant flavonoids, proanthocyanidins oligomers. These flavonoids are poten...

The effect of pure phenol on sperm parameters and fertility rate in male mice

Background: Phenol is an estrogenic and toxic compound and people are widely exposed to it, in different ways.  OBJECTIVES: The aim of this study was to determine  the  negative effects of phenol on the fertility of male mice, by investigating sperm parameters including viability, motility, fertility rates and daily sperm production (DSP). METHODS: A total of 106 adult NIH mice were divided int...

Impact of trisomy on fertility and meiosis in male mice.

BACKGROUND Chromosomal abnormalities frequently are associated with impairment or arrest of spermatogenesis in mammals but are compatible with fertility in female carriers of the same anomaly. In the case of trisomy, mice have extra genomic DNA as well as the chromosomal abnormality, usually present as an extra, unpaired chromosome. Thus, impairment of spermatogenesis in trisomic males could be...

Disruption of Chtf18 Causes Defective Meiotic Recombination in Male Mice

CHTF18 (chromosome transmission fidelity factor 18) is an evolutionarily conserved subunit of the Replication Factor C-like complex, CTF18-RLC. CHTF18 is necessary for the faithful passage of chromosomes from one daughter cell to the next during mitosis in yeast, and it is crucial for germline development in the fruitfly. Previously, we showed that mouse Chtf18 is expressed throughout the germl...

Study on The Reproductive Organs and Fertility of The Male Mice following Administration of Metronidazole